在城里做小本生意的老杨阴差阳错住进龙江路十号院，与脾气火爆的单亲妈妈杨琴成为了一对邻居。二人因一系列生活琐事产生冲突，从小打小闹，到水火不容，泼辣的杨琴仗着利落的身手不断地“修理”着老杨，老杨则依靠自己的机智与幽默与杨琴不断周旋。杨琴的父母喜欢上了厚道而热心的老杨，一心想把他收作上门女婿；杨琴的儿子杨过与老杨的关系也从剑拔驽张逐渐变得亲如父子。在众多亲友的帮助下，大气仗义的老杨，最终让杨琴刮目相看，并赢得了她真诚无私的爱情。当二人准备共同走向新生活的时候，杨琴的前夫吴维突然出现了。扬琴面对身分地位悬殊的两个男人老杨和吴维，义无反顾地把目光投向在自己日常生活中难以割舍的老杨。
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